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This table makes the distinction painfully clear

Finally, the increased (the present ischemia/reperfusion study) or decreased (inferior caval vein occlusion study) (Vukojevic et al., 2018) expression of Vegfr2 that coincides with continuously increased Nos3 expression may reflect particularities of the organization of the response in the hippocampus after bilateral carotid artery ligation during reperfusion and ischemia in rats with occluded inferior caval veins (Vukojevic et al., 2018)

And unlike many pain medications, it doesn't produce sedation, addiction, or cognitive impairment

Yet for a significant subset of men on TRT, that is exactly what happens, and understanding why requires looking past total testos